The Investigation Department

The DCRI Investigation Department is responsible for patients enrolled in clinical trials at the Oscar Lambret Center. It is a multidisciplinary department that includes an integrated care unit: the patients enrolled are taken care of in this dedicated unit, centralized within the Investigation Department. It is responsible for overseeing the logistical and regulatory aspects of all the trials conducted at the Oscar Lambret Center sponsored by the pharmaceutical industry, cooperative and academic groups and all research with institutional sponsors. It studies the trials’ feasibility and selects them together with the principal investigator and is in charge of all the logistic aspects of the clinical trials conducted: implementation, monitoring enrolment, patient follow-up, data collection and preparing audits and inspections and archiving. It relays with the sponsors’ operational staff.

The team guarantees the safety of the patients enrolled in these trials.


The excellence of the clinical research at the Oscar Lambret Center was recognized in 2014 when it obtained the CLIP² certification (INCa-certified early phase center), which was renewed in 2019 (OLC coordination, Prof. Penel).

Of the 16 centers certified in France by the National Cancer Institute (INCa), the Lille early phase clinical trial center, Lille CLIP², supported by the Oscar Lambret Center and Lille Regional University Hospital under the aegis of the Regional Cancer Reference Center (C2RC), is one of the 7 sites to be recognized for its expertise in the care of both adult and pediatric patients.

The structured diagnostic expertise of the two facilities offers patients in the region optimal medical care and facilitates their access to suitable early phase trials. The Lille CLIP² thus reinforces the structures and resources dedicated to clinical cancer research. By increasing access to early phase trials, it gives more patients access to novel treatments.

At the Oscar Lambret Center, adult patient care is coordinated by Pr Nicolas Penel, while the pediatric CLIP is coordinated by Dr Anne-Sophie Defachelles.

An interregional patient referral network has been created to offer patients in the surrounding regions the greatest opportunity to access novel treatments (Lille and Normandy CLIP²) that extend to trials at the Curie Institute (Paris) and the Jules Bordet Institute (Brussels). Weekly meetings are therefore organized to discuss cases referred and already centralized.  

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